- Sechrist Mill
- Second Island
- Sedgwick
- Sedwicks Mill
- Seeger Place
- Seelyville
- Seemsville
- Seger
- Seiberlingville
- Seidersville
- Seiple
- Seipstown
- Seisholtzville
- Seitzland
- Seitzville
- Seldersville
- Selea
- Selinsgrove
- Selinsgrove Junction
- Selkirk
- Sellersville
- Sellersville Heights
- Selsie Village
- Seltzer
- Seminole
- Seneca
- Sereno
- Sergeant
- Serpentine Acres
- Seven Acres