- Saint Andrews
- Saint Charles
- Saint George
- Saint Helena Island
- Saint Johns
- Saint Johns Crossroads
- Saint Julian
- Saint Matthews
- Saint Paul
- Saint Paul Forks
- Saint Pauls
- Saint Phillips
- Saint Phillips Island
- Saint Stephen
- Salak
- Salem
- Salem
- Salem
- Salem Crossroads
- Salem Crossroads
- Salem Estates
- Salem Plantation
- Salisbury Acres
- Salkehatchie
- Salley
- Salt Creek
- Salt Marsh Cove
- Salters
- Salters Depot
- Saluca