S
- (Chris Hani District Municipality) Southeyville
- (OR Tambo District Municipality) South African National Tuberculosis Settlement
- (Amathole District Municipality) Soto
- (Joe Gqabi District Municipality) Sorgvliet
- (Chris Hani District Municipality) Sonskyn
- (Sarah Baartman District Municipality) Sonop
- (Joe Gqabi District Municipality) Sonnig
- (Joe Gqabi District Municipality) Sonneblom
- (Amathole District Municipality) Sonkana
- (Joe Gqabi District Municipality) Somerton
- (Alfred Nzo District Municipality) Somabadi
- (Joe Gqabi District Municipality) Soetfontein
- (Alfred Nzo District Municipality) Snakefield
- (Joe Gqabi District Municipality) Smitsrust
- (Chris Hani District Municipality) Smithsriviere
- (Chris Hani District Municipality) Smithfield
- (Joe Gqabi District Municipality) Smiling Valley
- (Sarah Baartman District Municipality) Smaldeel
- (Joe Gqabi District Municipality) Smaldeel
- (Chris Hani District Municipality) Sleeohoek
- (Chris Hani District Municipality) Slaapkop
- (Nelson Mandela Bay Metropolitan Municipality) Skoenmakerskop
- (Joe Gqabi District Municipality) Skoemansdrif
- (Joe Gqabi District Municipality) Skisazana
- (Joe Gqabi District Municipality) Skilderkrans
- (Chris Hani District Municipality) Skikplaas
- (Chris Hani District Municipality) Skietlegte
- (Chris Hani District Municipality) Skietfontein
- (Amathole District Municipality) Sizini
- (OR Tambo District Municipality) Sizindini