- South Effingham
- Sabattus Heights
- Sachem Village
- Sagamore Grove
- Salem
- Salem Depot
- Salisbury
- Salisbury Heights
- Samoset
- Sanborn
- Sanborn Corners
- Sanbornton
- Sanbornville
- Sandown
- Sandwich
- Sandwich Landing
- Sandy Island
- Sargent Corners
- Savageville
- Sawyers
- Sawyers River
- Scates Corner
- Scavenger Island
- Scotland
- Scott
- Scribners Corner
- Seabrook
- Seabrook Beach
- Seabrook Station
- Seacrest Village