- Shindler
- Silver City
- Silver Lake Colony
- Silver Valley Addition
- Sinai
- Sioux Falls
- Sioux Falls Junction
- Sioux Village
- Sisseton
- Sitka
- Skeleton Island
- Skunk Island
- Skunk Island (historical)
- Skyline Heights
- Slim Butte
- Smiths Park
- Smithwick
- Snake Creek
- Soldier Creek
- Sorum
- Sorum Addition
- Sorum Heights
- South Canyon Country Estates
- South Dakota Park
- South Shore
- Spain
- Spearfish
- Spencer
- Spink
- Spink Colony