- Eagle Center
- Eagle City
- Eagle Grove
- Eagle Point
- Eagle Ridge Community
- Earlham
- Earling
- Earlville
- Early
- Easley
- East Amana
- East Canton
- East Creston
- East Des Moines
- East Monticello
- East Ottumwa
- East Peru
- East Pleasant Plain
- East Rapids
- East Rickardsville
- Eastgate Estate Park
- Easton Place
- Ebys Mill
- Echo
- Echo Valley Mobile Home Park
- Eckards
- Eddyville
- Eden
- Edenville
- Edgewood