- Edgemere
- Edgemoor
- Edgewater Park
- Edinburgh
- Edings Island
- Edisto
- Edisto Beach
- Edisto Club
- Edisto Island
- Edmund
- Edwards
- Edwards Forest Heights
- Effingham
- Ehrhardt
- Eison Crossroads
- Ekom
- El Bethel
- Eleven Oaks
- Elgin
- Elgin Acres
- Elgin Woods
- Elim
- Elizabeth Heights
- Elko
- Ella
- Ellenwood Acres
- Ellerbees Mill
- Elliott
- Elloree
- Ellwood