- Scott
- Scott
- Scottsville
- Scout Island
- Scranton
- Scurry
- Sea Pines
- Sea Pines Circle
- Sea Pines Plantation
- Seabreeze
- Seabrook
- Seabrook
- Seabrook Island
- Seabrook Landing
- Seacroft
- Seaside
- Seaside Farms Estates
- Seaton
- Secessionville
- Secessionville Acres
- Sedalia
- Segars
- Seiglers Crossroads
- Seigling
- Seivern
- Sellars Heights
- Sellers
- Selma
- Seloc
- Selwood Shores